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Target
Proteasome subunit beta type-5
Ligand
BDBM50234984
Substrate
n/a
Meas. Tech.
ChEMBL_2024064 (CHEMBL4677877)
IC50
1.2±n/a nM
Citation
 Zhao, Y; Xu, L; Zhang, J; Zhang, M; Lu, J; He, R; Xi, J; Zhuang, R; Li, J; Zhou, Y Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors. Bioorg Med Chem 29:0 (2021) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50234984
Synonyms:
CHEMBL3218837
Type:
Small organic molecule
Emp. Form.:
C34H37ClN6O5
Mol. Mass.:
645.148
SMILES:
CC(C)(C)CNC(=O)C[C@H](NC(=O)C(=O)c1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCc1ccccc1Cl |r|
Structure:
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