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Target
Estrogen receptor
Ligand
BDBM485045
Substrate
n/a
Meas. Tech.
ChEMBL_2027418 (CHEMBL4681576)
IC50
649±n/a nM
Citation
 Kim, J; Woo, SY; Im, CY; Yoo, EK; Lee, S; Kim, HJ; Hwang, HJ; Cho, JH; Lee, WS; Yoon, H; Kim, S; Kwon, OB; Hwang, H; Kim, KH; Jeon, JH; Singh, TD; Kim, SW; Hwang, SY; Choi, HS; Lee, IK; Kim, SH; Jeon, YH; Chin, J; Cho, SJ Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor ? (ERR?) Inverse Agonists. J Med Chem 59:10209-10227 (2016) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM485045
Synonyms:
US10934303, Cmpd No. 6e | US10934303, Example 5 | US11285226, Compound 6e
Type:
Small organic molecule
Emp. Form.:
C29H33NO3
Mol. Mass.:
443.5772
SMILES:
OCCC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN2CCCC2)cc1)c1ccccc1
Structure:
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