Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM50045936
Substrate
n/a
Meas. Tech.
ChEMBL_2045307 (CHEMBL4700006)
Ki
136000±n/a nM
Citation
Muller, J; Cardey, B; Zedet, A; Desingle, C; Grzybowski, M; Pomper, P; Foley, S; Harakat, D; Ramseyer, C; Girard, C; Pudlo, M Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors. RSC Med Chem 11:559-568 (2020) [PubMed] Article
More Info.:
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_BOVIN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
35008.90
Organism:
Bovine
Description:
ChEMBL_474406
Residue:
322
Sequence:
MSSKPQSIGVIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKELECDVKDYGDLSFADNLDDSPFQIVKNPRCVGKASEKLADVVAEVKKTGRISLVLGGDHSLAIGSISGHARVHPDLCVIWVDAHTDINTPLTTKTGNLHGQPVSFLLKELKEKMPEVPGFYWVAPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVQGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTTVAITMACFGVAREGNHKPIDYLSPPK
Inhibitor
Name:
BDBM50045936
Synonyms:
(E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-Piceatannol | 3,3',4,5'-tetrahydroxystilbene | 3,4,3',5'-tetrahydroxy-trans-stilbene | 3,4,3',5'-tetrahydroxystillbene | 4-(3,5-dihydroxystyryl)benzene-1,2-diol | 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol | 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol(Piceatannol) | 4-[2-(3,5-dihydroxyphenyl)-(E)-1-ethenyl]-1,2-benzenediol | 4-[2-(3,5-dihydroxyphenyl)-(E)-1-ethenyl]-1,2-benzenediol(Piceatannol) | CHEMBL69863 | NSC-365798 | US11866416, Example 8 | cid_667639 | piceatanol | trans-3,3',4,5'-tetrahydroxystilbene
Type:
Small organic molecule
Emp. Form.:
C14H12O4
Mol. Mass.:
244.2427
SMILES:
Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1