Reaction Details Report a problem with these data
Target
Natural resistance-associated macrophage protein 2
Ligand
BDBM50553222
Substrate
n/a
Meas. Tech.
ChEMBL_2045558 (CHEMBL4700257)
IC50
350±n/a nM
Citation
 Poirier, M; Pujol-Giménez, J; Manatschal, C; Bühlmann, S; Embaby, A; Javor, S; Hediger, MA; Reymond, JL Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation. RSC Med Chem 11:1023-1031 (2020) [PubMed]  Article 
Target
Name:
Natural resistance-associated macrophage protein 2
Synonyms:
DCT1 | DMT-1 | DMT1 | Divalent cation transporter 1 | Divalent metal transporter 1 | NRAM2_HUMAN | NRAMP 2 | NRAMP2 | SLC11A2
Type:
PROTEIN
Mol. Mass.:
62262.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_795244
Residue:
568
Sequence:
MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTCHLGLTAQPELYLLNTMDADSLVSR
  
Inhibitor
Name:
BDBM50553222
Synonyms:
CHEMBL1197758
Type:
Small organic molecule
Emp. Form.:
C13H20N4S2
Mol. Mass.:
296.455
SMILES:
Cc1cc(C)c(CSC(N)=N)c(C)c1CSC(N)=N
Structure:
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