Reaction Details Report a problem with these data
Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM355934
Substrate
n/a
Meas. Tech.
ChEMBL_2051223 (CHEMBL4705922)
IC50
10.0±n/a nM
Citation
Quancard, J; Simic, O; Pissot Soldermann, C; Aichholz, R; Blatter, M; Renatus, M; Erbel, P; Melkko, S; Endres, R; Sorge, M; Kieffer, L; Wagner, T; Beltz, K; Mcsheehy, P; Wartmann, M; Régnier, CH; Calzascia, T; Radimerski, T; Bigaud, M; Weiss, A; Bornancin, F; Schlapbach, A Optimization of the J Med Chem 63:14594-14608 (2020) [PubMed] Article
More Info.:
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Human
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
Inhibitor
Name:
BDBM355934
Synonyms:
1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7-(tetrahydro- 2H-pyran-4- yl)pyrazolo[1,5- a]pyrimidin-6-yl)urea | US10442808, Example 58 | US9815842, Example 58
Type:
Small organic molecule
Emp. Form.:
C19H17Cl2N9O2
Mol. Mass.:
474.303
SMILES:
Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCOCC3)n2n1