Reaction Details
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Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM355921
Substrate
n/a
Meas. Tech.
ChEMBL_2051223 (CHEMBL4705922)
IC50
3.0±n/a nM
Citation
Quancard, J; Simic, O; Pissot Soldermann, C; Aichholz, R; Blatter, M; Renatus, M; Erbel, P; Melkko, S; Endres, R; Sorge, M; Kieffer, L; Wagner, T; Beltz, K; Mcsheehy, P; Wartmann, M; Régnier, CH; Calzascia, T; Radimerski, T; Bigaud, M; Weiss, A; Bornancin, F; Schlapbach, A Optimization of the J Med Chem 63:14594-14608 (2020) [PubMed] Article More Info.:
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Human
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
Inhibitor
Name:
BDBM355921
Synonyms:
(R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7-(1- methoxypropan-2- yl)pyrazolo[1,5- a]pyrimidin-6-yl)urea | US10442808, Example 45 | US9815842, Example 45
Type:
Small organic molecule
Emp. Form.:
C18H17Cl2N9O2
Mol. Mass.:
462.293
SMILES:
COC[C@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12 |r|
Structure:
