Reaction Details
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5-hydroxytryptamine receptor 6
Ligand
BDBM50556387
Substrate
n/a
Meas. Tech.
ChEMBL_2056034 (CHEMBL4711035)
Ki
54±n/a nM
Citation
Canale, V; Grychowska, K; Kurczab, R; Ryng, M; Keeri, AR; Sata?a, G; Olejarz-Maciej, A; Koczurkiewicz, P; Drop, M; Blicharz, K; Piska, K; P?kala, E; Janiszewska, P; Krawczyk, M; Walczak, M; Chaumont-Dubel, S; Bojarski, AJ; Marin, P; Popik, P; Zajdel, P A dual-acting 5-HT Eur J Med Chem 208:0 (2020) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Human
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
Inhibitor
Name:
BDBM50556387
Synonyms:
CHEMBL4761469
Type:
Small organic molecule
Emp. Form.:
C33H38N4O3S
Mol. Mass.:
570.745
SMILES:
CN(CC#C)Cc1ccc(OCCCCN2CCN(CC2)c2cccc3n(ccc23)S(=O)(=O)c2ccccc2)cc1
Structure:
