Reaction Details Report a problem with these data
Target
Type II inositol 1,4,5-trisphosphate 5-phosphatase
Ligand
BDBM50558483
Substrate
n/a
Meas. Tech.
ChEMBL_2063776 (CHEMBL4719029)
IC50
>200000±n/a nM
Citation
 He, R; Wang, J; Yu, ZH; Zhang, RY; Liu, S; Wu, L; Zhang, ZY Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism. J Med Chem 59:9094-9106 (2016) [PubMed]  Article 
Target
Name:
Type II inositol 1,4,5-trisphosphate 5-phosphatase
Synonyms:
3.1.3.36 | 5PTase | 75 kDa inositol polyphosphate-5-phosphatase | I5P2_HUMAN | INPP5B | OCRL2 | Phosphoinositide 5-phosphatase | Type II inositol 1,4,5-trisphosphate 5-phosphatase
Type:
PROTEIN
Mol. Mass.:
112830.72
Organism:
Homo sapiens
Description:
ChEMBL_19622
Residue:
993
Sequence:
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRYPSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL
  
Inhibitor
Name:
BDBM50558483
Synonyms:
CHEMBL4778085
Type:
Small organic molecule
Emp. Form.:
C17H14N2O4S
Mol. Mass.:
342.369
SMILES:
OS(=O)(=O)C(C(=O)Nc1cnc2ccccc2c1)c1ccccc1
Structure:
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