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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50111332
Substrate
n/a
Meas. Tech.
ChEMBL_139759 (CHEMBL748895)
Ki
0.9±n/a nM
Citation
 Wang, Y; Chackalamannil, S; Hu, Z; Greenlee, WJ; Clader, J; Boyle, CD; Kaminski, JJ; Billard, W; Binch, H; Crosby, G; Ruperto, V; Duffy, RA; Cohen-Williams, M; Coffin, VL; Cox, KA; Grotz, DE; Lachowicz, JE Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists. J Med Chem 45:5415-8 (2002) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50111332
Synonyms:
CHEMBL276239 | [4-(4-Isopropylsulfanyl-benzyl)-[1,4']bipiperidinyl-1'-yl]-naphthalen-1-yl-methanone
Type:
Small organic molecule
Emp. Form.:
C31H38N2OS
Mol. Mass.:
486.711
SMILES:
CC(C)Sc1ccc(CC2CCN(CC2)C2CCN(CC2)C(=O)c2cccc3ccccc23)cc1
Structure:
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