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Target
Mitogen-activated protein kinase 11
Ligand
BDBM50122910
Substrate
n/a
Meas. Tech.
ChEMBL_124648 (CHEMBL731909)
IC50
153±n/a nM
Citation
 Colletti, SL; Frie, JL; Dixon, EC; Singh, SB; Choi, BK; Scapin, G; Fitzgerald, CE; Kumar, S; Nichols, EA; O'Keefe, SJ; O'Neill, EA; Porter, G; Samuel, K; Schmatz, DM; Schwartz, CD; Shoop, WL; Thompson, CM; Thompson, JE; Wang, R; Woods, A; Zaller, DM; Doherty, JB Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones. J Med Chem 46:349-52 (2003) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP Kinase p38 beta | MK11_MOUSE | Mapk11 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | Prkm11 | p38B
Type:
Enzyme
Mol. Mass.:
41390.66
Organism:
Mus musculus (mouse)
Description:
Q9WUI1
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTHEIEQ
  
Inhibitor
Name:
BDBM50122910
Synonyms:
2-(2,6-Dichloro-phenyl)-6-[2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-2H-pyridazin-3-one | 2-(2,6-dichlorophenyl)-6-(2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)pyridazin-3(2H)-one | CHEMBL117109
Type:
Small organic molecule
Emp. Form.:
C23H13Cl2FN4O
Mol. Mass.:
451.28
SMILES:
Fc1ccc(cc1)-c1nc2ccccn2c1-c1ccc(=O)n(n1)-c1c(Cl)cccc1Cl |(-4.28,-10.03,;-3.48,-8.71,;-4.22,-7.36,;-3.43,-6.05,;-1.89,-6.08,;-1.14,-7.42,;-1.94,-8.74,;-1.1,-4.75,;.4,-5.08,;1.17,-3.75,;2.67,-3.44,;3.16,-1.98,;2.13,-.83,;.62,-1.14,;.15,-2.6,;-1.27,-3.22,;-2.6,-2.44,;-3.93,-3.21,;-5.26,-2.43,;-5.26,-.9,;-6.59,-.13,;-3.92,-.13,;-2.59,-.9,;-3.92,1.41,;-5.25,2.18,;-6.59,1.41,;-5.25,3.72,;-3.92,4.49,;-2.59,3.73,;-2.58,2.18,;-1.25,1.41,)|
Structure:
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