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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50123002
Substrate
n/a
Meas. Tech.
ChEBML_124499
IC50
22±n/a nM
Citation
 Rupert, KC; Henry, JR; Dodd, JH; Wadsworth, SA; Cavender, DE; Olini, GC; Fahmy, B; Siekierka, JJ Imidazopyrimidines, potent inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 13:347-50 (2003) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha
Type:
Enzyme
Mol. Mass.:
41281.22
Organism:
Mus musculus (mouse)
Description:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography.
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50123002
Synonyms:
2-Benzyl-7-(4-fluoro-phenyl)-8-pyridin-4-yl-3,6-dihydro-imidazo[4,5-e]indole | 2-benzyl-7-(4-fluorophenyl)-8-(pyridin-4-yl)-3,6-dihydroimidazo[4,5-e]indole | CHEMBL331215
Type:
Small organic molecule
Emp. Form.:
C27H19FN4
Mol. Mass.:
418.465
SMILES:
Fc1ccc(cc1)-c1[nH]c2ccc3[nH]c(Cc4ccccc4)nc3c2c1-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: