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Target
Succinate receptor 1
Ligand
BDBM50561194
Substrate
n/a
Meas. Tech.
ChEMBL_2074424 (CHEMBL4729958)
IC50
25±n/a nM
Citation
 Velcicky, J; Wilcken, R; Cotesta, S; Janser, P; Schlapbach, A; Wagner, T; Piechon, P; Villard, F; Bouhelal, R; Piller, F; Harlfinger, S; Stringer, R; Fehlmann, D; Kaupmann, K; Littlewood-Evans, A; Haffke, M; Gommermann, N Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure. J Med Chem 63:9856-9875 (2020) [PubMed]  Article 
Target
Name:
Succinate receptor 1
Synonyms:
G-protein coupled receptor 91 | GPR91 | P2Y purinoceptor 1-like | SUCNR1 | SUCR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
38709.48
Organism:
Human
Description:
ChEMBL_852820
Residue:
334
Sequence:
MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
  
Inhibitor
Name:
BDBM50561194
Synonyms:
CHEMBL4790324
Type:
Small organic molecule
Emp. Form.:
C27H29N3O3
Mol. Mass.:
443.5375
SMILES:
CN1CCN(Cc2ccc(cc2)-c2cccc(c2)C(=O)Nc2ccccc2CC(O)=O)CC1
Structure:
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