Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM100954
Substrate
n/a
Meas. Tech.
ChEMBL_2075296 (CHEMBL4730830)
IC50
8.8±n/a nM
Citation
 Liu, H; Niu, D; Tham Sjin, RT; Dubrovskiy, A; Zhu, Z; McDonald, JJ; Fahnoe, K; Wang, Z; Munson, M; Scholte, A; Barrague, M; Fitzgerald, M; Liu, J; Kothe, M; Sun, F; Murtie, J; Ge, J; Rocnik, J; Harvey, D; Ospina, B; Perron, K; Zheng, G; Shehu, E; D'Agostino, LA Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma. ACS Med Chem Lett 11:1899-1904 (2020) [PubMed]  Article 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Human
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM100954
Synonyms:
US10189794, Compound I-241 | US10618902, Compound I-241 | US10774052, Compound I-241 | US9695132, I-241
Type:
Small organic molecule
Emp. Form.:
C23H23Cl2N5O5
Mol. Mass.:
520.365
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O |r,wU:19.19,23.25,(9.29,-1.34,;9.29,.2,;7.95,.97,;7.95,2.51,;6.62,3.28,;6.62,4.82,;5.29,5.59,;5.29,2.51,;3.95,3.28,;5.29,.97,;6.62,.2,;6.62,-1.34,;3.95,.2,;2.62,.97,;1.28,.2,;-.05,.97,;-1.38,.2,;-1.38,-1.34,;-2.72,-2.11,;-4.05,-1.34,;-4.05,.2,;-5.51,.67,;-6.42,-.57,;-5.51,-1.82,;-5.91,-3.3,;-7.4,-3.7,;-8.49,-2.61,;-7.8,-5.19,;-9.29,-5.59,;-.05,-2.11,;1.28,-1.34,;2.62,-2.11,;2.62,-3.65,;3.95,-1.34,;5.29,-2.11,)|
Structure:
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