Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM50126579
Substrate
n/a
Meas. Tech.
ChEBML_48455
Ki
35±n/a nM
Citation
 Klingler, O; Matter, H; Schudok, M; Bajaj, SP; Czech, J; Lorenz, M; Nestler, HP; Schreuder, H; Wildgoose, P Design, synthesis, and structure-activity relationship of a new class of amidinophenylurea-based factor VIIa inhibitors. Bioorg Med Chem Lett 13:1463-7 (2003) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Human
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50126579
Synonyms:
2-[3-(4-Carbamimidoyl-phenyl)-ureido]-N-[(S)-1-(3-methoxy-phenyl)-ethyl]-acetamide | 2-[3-(4-Carbamimidoyl-phenyl)-ureido]-N-[1-((S)-3-methoxy-phenyl)-ethyl]-acetamide | CHEMBL34887
Type:
Small organic molecule
Emp. Form.:
C19H23N5O3
Mol. Mass.:
369.4176
SMILES:
COc1cccc(c1)[C@H](C)NC(=O)CNC(=O)Nc1ccc(cc1)C(N)=N
Structure:
Search PDB for entries with ligand similarity: