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Target
Dual specificity protein phosphatase 3
Ligand
BDBM50564158
Substrate
n/a
Meas. Tech.
ChEMBL_2086927 (CHEMBL4768190)
IC50
56900±n/a nM
Citation
 Hou, X; Sun, JP; Ge, L; Liang, X; Li, K; Zhang, Y; Fang, H Inhibition of striatal-enriched protein tyrosine phosphatase by targeting computationally revealed cryptic pockets. Eur J Med Chem 190:0 (2020) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Human
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50564158
Synonyms:
CHEMBL4794022
Type:
Small organic molecule
Emp. Form.:
C25H20BrClN2O4S
Mol. Mass.:
559.859
SMILES:
OC(=O)c1cccc2C3C(Cl)C(CC3C(Nc12)c1cccc(Br)c1)Sc1ccccc1[N+]([O-])=O
Structure:
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