Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50564176
Substrate
n/a
Meas. Tech.
ChEMBL_2086972 (CHEMBL4768235)
Ki
1.5±n/a nM
Citation
 Xiong, J; Jin, J; Gao, L; Hao, C; Liu, X; Liu, BF; Chen, Y; Zhang, G Piperidine propionamide as a scaffold for potent sigma-1 receptor antagonists and mu opioid receptor agonists for treating neuropathic pain. Eur J Med Chem 191:0 (2020) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50564176
Synonyms:
CHEMBL4797982
Type:
Small organic molecule
Emp. Form.:
C24H32N2O2
Mol. Mass.:
380.5231
SMILES:
CCC(=O)N(CCN1CCC(Cc2ccccc2)CC1)c1ccc(OC)cc1
Structure:
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