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Target
Histamine H3 receptor
Ligand
BDBM50129254
Substrate
n/a
Meas. Tech.
ChEMBL_87057 (CHEMBL697959)
Ki
18±n/a nM
Citation
 Turner, SC; Esbenshade, TA; Bennani, YL; Hancock, AA A new class of histamine H(3)-receptor antagonists: synthesis and structure-activity relationships of 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolines. Bioorg Med Chem Lett 13:2131-5 (2003) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50129254
Synonyms:
CHEMBL303824 | [2-(1-Methyl-pyrrolidin-2-yl)-ethyl]-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-amine
Type:
Small organic molecule
Emp. Form.:
C21H29N3
Mol. Mass.:
323.4751
SMILES:
CN1CCCC1CCNc1c2CCCCCc2nc2ccccc12
Structure:
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