Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50566090
Substrate
n/a
Meas. Tech.
ChEMBL_2094458 (CHEMBL4775721)
Ki
332±n/a nM
Citation
 Yukawa-Takamatsu, K; Wang, Y; Watanabe, M; Takamura, Y; Fujihara, M; Nakamura-Nakayama, M; Yamada, S; Kikuzawa, S; Makishima, M; Kawasaki, M; Ito, S; Nakano, S; Kakuta, H Convenient Retinoid X Receptor Binding Assay Based on Fluorescence Change of the Antagonist NEt-C343. J Med Chem 64:861-870 (2021) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50566090
Synonyms:
CHEMBL4788526
Type:
Small organic molecule
Emp. Form.:
C37H42N4O6
Mol. Mass.:
638.7526
SMILES:
CCN(c1ccc(cn1)C(O)=O)c1cc(OCC(C)C)c(cc1NC(=O)c1cc2cc3CCCN4CCCc(c34)c2oc1=O)C(C)C
Structure:
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