Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50257659
Substrate
n/a
Meas. Tech.
ChEMBL_2094495 (CHEMBL4775758)
EC50
34±n/a nM
Citation
 Jiang, BE; Jiang, X; Zhang, Q; Liang, Q; Qiu, ZL; Sun, XB; Yang, JJ; Chen, S; Yi, C; Chai, X; Liu, M; Yu, LF; Lu, W; Zhang, HK From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis. J Med Chem 64:385-403 (2021) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50257659
Synonyms:
CHEMBL4104511
Type:
Small organic molecule
Emp. Form.:
C24H32N2O
Mol. Mass.:
364.5237
SMILES:
CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2ccccc12 |TLB:14:15:12.13.18:19,THB:14:13:19:20.15.16,16:15:12:18.17.19,16:17:12:20.14.15|
Structure:
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