Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50566132
Substrate
n/a
Meas. Tech.
ChEMBL_2094498 (CHEMBL4775761)
EC50
100000±n/a nM
Citation
 Jiang, BE; Jiang, X; Zhang, Q; Liang, Q; Qiu, ZL; Sun, XB; Yang, JJ; Chen, S; Yi, C; Chai, X; Liu, M; Yu, LF; Lu, W; Zhang, HK From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis. J Med Chem 64:385-403 (2021) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50566132
Synonyms:
CHEMBL4783974
Type:
Small organic molecule
Emp. Form.:
C19H27N3O2
Mol. Mass.:
329.4366
SMILES:
Cc1ccc(cc1)-n1nc(cc1C(C)(C)C)C(=O)NC(C)(C)CO
Structure:
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