Reaction Details Report a problem with these data
Target
P2Y purinoceptor 14
Ligand
BDBM50566405
Substrate
n/a
Meas. Tech.
ChEMBL_2100291 (CHEMBL4808687)
IC50
19±n/a nM
Citation
 Jung, YH; Salmaso, V; Wen, Z; Bennett, JM; Phung, NB; Lieberman, DI; Gopinatth, V; Randle, JCR; Chen, Z; Salvemini, D; Karcz, TP; Cook, DN; Jacobson, KA Structure-Activity Relationship of Heterocyclic P2Y J Med Chem 64:5099-5122 (2021) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 14
Synonyms:
G-protein coupled receptor 105 | Gpr105 | P2Y14 | P2Y14_MOUSE | P2ry14 | UDP-glucose receptor
Type:
PROTEIN
Mol. Mass.:
38883.93
Organism:
Mus musculus
Description:
ChEMBL_745158
Residue:
338
Sequence:
MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL
  
Inhibitor
Name:
BDBM50566405
Synonyms:
CHEMBL4864408
Type:
Small organic molecule
Emp. Form.:
C28H18F3NO4
Mol. Mass.:
489.442
SMILES:
OCc1cc(no1)-c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Structure:
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