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Target
Adenosine kinase
Ligand
BDBM50135892
Substrate
n/a
Meas. Tech.
ChEMBL_31115 (CHEMBL642226)
IC50
22000±n/a nM
Citation
 Perner, RJ; Gu, YG; Lee, CH; Bayburt, EK; McKie, J; Alexander, KM; Kohlhaas, KL; Wismer, CT; Mikusa, J; Jarvis, MF; Kowaluk, EA; Bhagwat, SS 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase. J Med Chem 46:5249-57 (2003) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50135892
Synonyms:
7-(4-Chloro-phenyl)-4-morpholin-4-yl-pteridine | CHEMBL151553
Type:
Small organic molecule
Emp. Form.:
C16H14ClN5O
Mol. Mass.:
327.768
SMILES:
Clc1ccc(cc1)-c1cnc2c(ncnc2n1)N1CCOCC1
Structure:
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