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Target
Presenilins-associated rhomboid-like protein, mitochondrial
Ligand
BDBM50572956
Substrate
n/a
Meas. Tech.
ChEMBL_2118696 (CHEMBL4827762)
IC50
1900±n/a nM
Citation
 Parsons, WH; Rutland, NT; Crainic, JA; Cardozo, JM; Chow, AS; Andrews, CL; Sheehan, BK Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL. Bioorg Med Chem Lett 49:0 (2021) [PubMed]  Article 
Target
Name:
Presenilins-associated rhomboid-like protein, mitochondrial
Synonyms:
3.4.21.105 | Mitochondrial intramembrane cleaving protease PARL | P-beta | PARL | PARL_HUMAN | PSARL | PSARL | Pbeta | Presenilins-associated rhomboid-like protein, mitochondrial
Type:
PROTEIN
Mol. Mass.:
42212.72
Organism:
Homo sapiens
Description:
ChEMBL_120480
Residue:
379
Sequence:
MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKVEPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK
  
Inhibitor
Name:
BDBM50572956
Synonyms:
CHEMBL4855230
Type:
Small organic molecule
Emp. Form.:
C16H13NO5S
Mol. Mass.:
331.343
SMILES:
O=C1CCC(=O)N1OS(=O)(=O)c1ccc(cc1)-c1ccccc1
Structure:
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