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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM50573208
Substrate
n/a
Meas. Tech.
ChEMBL_2119186 (CHEMBL4828252)
IC50
5000±n/a nM
Citation
 Han, Y; Zhang, H; Wang, S; Li, B; Xing, K; Shi, Y; Cao, H; Zhang, J; Tong, T; Zang, J; Guan, L; Gao, X; Wang, Y; Liu, D; Huang, M; Jing, Y; Zhao, L Optimization of 4,6-Disubstituted Pyrido[3,2- J Med Chem 64:13719-13735 (2021) [PubMed]  Article 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM50573208
Synonyms:
CHEMBL4867333
Type:
Small organic molecule
Emp. Form.:
C26H21ClN6O
Mol. Mass.:
468.938
SMILES:
Clc1ccc2ncnc(Nc3ccccc3C#Cc3cccc(c3)C(=O)N3CCNCC3)c2n1
Structure:
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