Reaction Details Report a problem with these data
Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM50573231
Substrate
n/a
Meas. Tech.
ChEMBL_2119186 (CHEMBL4828252)
IC50
41±n/a nM
Citation
 Han, Y; Zhang, H; Wang, S; Li, B; Xing, K; Shi, Y; Cao, H; Zhang, J; Tong, T; Zang, J; Guan, L; Gao, X; Wang, Y; Liu, D; Huang, M; Jing, Y; Zhao, L Optimization of 4,6-Disubstituted Pyrido[3,2- J Med Chem 64:13719-13735 (2021) [PubMed]  Article 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM50573231
Synonyms:
CHEMBL4848753
Type:
Small organic molecule
Emp. Form.:
C25H21F3N6O
Mol. Mass.:
478.469
SMILES:
FC(F)(F)c1ccc(Nc2ncnc3ccc(nc23)-c2ccc(cc2)C(=O)N2CCNCC2)cc1
Structure:
Search PDB for entries with ligand similarity: