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Target
Histamine H3 receptor
Ligand
BDBM50139332
Substrate
n/a
Meas. Tech.
ChEBML_86753
Ki
2.1±n/a nM
Citation
 Gfesser, GA; Zhang, H; Dinges, J; Fox, GB; Pan, JB; Esbenshade, TA; Yao, BB; Witte, D; Miller, TR; Kang, CH; Krueger, KM; Bennani, YL; Hancock, AA; Faghih, R Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists. Bioorg Med Chem Lett 14:673-6 (2004) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rat
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50139332
Synonyms:
CHEMBL158056 | Furan-2-carboxylic acid [(R)-2-(4-{3-[3-fluoro-4-(5-isopropyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-propyl}-[1,4]diazepan-1-yl)-1-methyl-2-oxo-ethyl]-amide
Type:
Small organic molecule
Emp. Form.:
C27H34FN5O5
Mol. Mass.:
527.5878
SMILES:
CC(C)c1nc(no1)-c1ccc(OCCCN2CCCN(CC2)C(=O)[C@@H](C)NC(=O)c2ccco2)cc1F
Structure:
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