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Target
Voltage-dependent L-type calcium channel subunit beta-2
Ligand
BDBM50573712
Substrate
n/a
Meas. Tech.
ChEMBL_2120423 (CHEMBL4829570)
IC50
41300±n/a nM
Citation
 Li, Y; Tan, WL; Guo, K; Gao, XW; Wei, J; Yi, D; Zhang, C; Wang, Q Synthesis and Biological Evaluation of Falcarinol-Type Analogues as Potential Calcium Channel Blockers. J Nat Prod 84:2138-2148 (2021) [PubMed]  Article 
Target
Name:
Voltage-dependent L-type calcium channel subunit beta-2
Synonyms:
CAB2 | CACB2_HUMAN | CACNB2 | CACNLB2 | Calcium channel voltage-dependent subunit beta 2 | L-type calcium channel alpha-1c/beta-2/alpha2delta-1 | Lambert-Eaton myasthenic syndrome antigen B | MYSB
Type:
PROTEIN
Mol. Mass.:
73595.87
Organism:
Homo sapiens
Description:
ChEMBL_117734
Residue:
660
Sequence:
MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
  
Inhibitor
Name:
BDBM50573712
Synonyms:
CHEBI:66722 | CHEMBL71260
Type:
Small organic molecule
Emp. Form.:
C17H24O
Mol. Mass.:
244.3719
SMILES:
CCCCCCC\C=C/CC#CC#C[C@H](O)C=C
Structure:
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