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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50576058
Substrate
n/a
Meas. Tech.
ChEMBL_2126430 (CHEMBL4835775)
IC50
12900±n/a nM
Citation
 Spinck, M; Bischoff, M; Lampe, P; Meyer-Almes, FJ; Sievers, S; Neumann, H Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1. J Med Chem 64:5838-5849 (2021) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50576058
Synonyms:
CHEMBL4869997
Type:
Small organic molecule
Emp. Form.:
C15H16N4O3S
Mol. Mass.:
332.378
SMILES:
CC(=O)Nc1nc(CN2CC(Oc3ccccc23)C(N)=O)cs1
Structure:
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