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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50576689
Substrate
n/a
Meas. Tech.
ChEMBL_2127689 (CHEMBL4837034)
Ki
351000±n/a nM
Citation
 Zhou, Y; Shen, W; Peng, J; Deng, Y; Li, X Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library. Bioorg Med Chem 45:0 (2021) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50576689
Synonyms:
CHEMBL4872893
Type:
Small organic molecule
Emp. Form.:
C29H35N3O5
Mol. Mass.:
505.6053
SMILES:
COc1cc(CC(=O)NCCCCCCNC(=O)c2cccc(c2)-c2cccnc2)cc(OC)c1OC
Structure:
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