Reaction Details Report a problem with these data
Target
Beta-secretase 1
Ligand
BDBM50577140
Substrate
n/a
Meas. Tech.
ChEMBL_2129520 (CHEMBL4838949)
IC50
34400±n/a nM
Citation
 Masuda, Y; Fujihara, K; Hayashi, S; Sasaki, H; Kino, Y; Kamauchi, H; Noji, M; Satoh, JI; Takanami, T; Kinoshita, K; Koyama, K Inhibition of BACE1 and Amyloid-? Aggregation by Meroterpenoids from the Mushroom  J Nat Prod 84:1748-1754 (2021) [PubMed]  Article 
Target
Name:
Beta-secretase 1
Synonyms:
ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:
Protein
Mol. Mass.:
55755.10
Organism:
Homo sapiens (Human)
Description:
P56817
Residue:
501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
  
Inhibitor
Name:
BDBM50577140
Synonyms:
CHEMBL4871044
Type:
Small organic molecule
Emp. Form.:
C23H34O6
Mol. Mass.:
406.5125
SMILES:
C\C(CC[C@H](O)C(C)(C)O)=C/CC\C(C)=C\Cc1c(O)cc(C)c(C(O)=O)c1O |r|
Structure:
Search PDB for entries with ligand similarity: