Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50144017
Substrate
n/a
Meas. Tech.
ChEBML_72991
Ki
400±n/a nM
Citation
 Kurukulasuriya, R; Sorensen, BK; Link, JT; Patel, JR; Jae, HS; Winn, MX; Rohde, JR; Grihalde, ND; Lin, CW; Ogiela, CA; Adler, AL; Collins, CA Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett 14:2047-50 (2004) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Human
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50144017
Synonyms:
3-{4-[2-(4-tert-Butyl-phenyl)-3-oxo-3-(4-p-tolyl-piperazin-1-yl)-propyl]-benzoylamino}-propionic acid | CHEMBL62863
Type:
Small organic molecule
Emp. Form.:
C34H41N3O4
Mol. Mass.:
555.707
SMILES:
Cc1ccc(cc1)N1CCN(CC1)C(=O)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)c1ccc(cc1)C(C)(C)C
Structure:
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