Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50577483
Substrate
n/a
Meas. Tech.
ChEMBL_2130287 (CHEMBL4839716)
Ki
120±n/a nM
Citation
 Rishton, GM; Look, GC; Ni, ZJ; Zhang, J; Wang, Y; Huang, Y; Wu, X; Izzo, NJ; LaBarbera, KM; Limegrover, CS; Rehak, C; Yurko, R; Catalano, SM Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease. ACS Med Chem Lett 12:1389-1395 (2021) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM50577483
Synonyms:
CHEMBL4869437
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2F3N
Mol. Mass.:
376.243
SMILES:
C[C@@H](CCc1ccc(Cl)c(Cl)c1)NCc1ccc(cc1)C(F)(F)F |r|
Structure:
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