Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349547
Substrate
n/a
Meas. Tech.
ChEMBL_2130287 (CHEMBL4839716)
Ki
8.5±n/a nM
Citation
 Rishton, GM; Look, GC; Ni, ZJ; Zhang, J; Wang, Y; Huang, Y; Wu, X; Izzo, NJ; LaBarbera, KM; Limegrover, CS; Rehak, C; Yurko, R; Catalano, SM Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease. ACS Med Chem Lett 12:1389-1395 (2021) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM349547
Synonyms:
US10207991, Ex. Cpd. No. 62 | US10611728, Example Compound 62 | US11691947, Example 62
Type:
Small organic molecule
Emp. Form.:
C24H33NO4S
Mol. Mass.:
431.588
SMILES:
CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Structure:
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