Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM50148958
Substrate
n/a
Meas. Tech.
ChEBML_48454
Ki
23±n/a nM
Citation
 Klingler, O; Matter, H; Schudok, M; Donghi, M; Czech, J; Lorenz, M; Nestler, HP; Szillat, H; Schreuder, H Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition. Bioorg Med Chem Lett 14:3715-20 (2004) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Human
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50148958
Synonyms:
2-[3-(4-Carbamimidoyl-phenyl)-ureido]-N-{1-[4-(3-chloro-benzyloxy)-phenyl]-ethyl}-acetamide | CHEMBL122599
Type:
Small organic molecule
Emp. Form.:
C25H26ClN5O3
Mol. Mass.:
479.959
SMILES:
CC(NC(=O)CNC(=O)Nc1ccc(cc1)C(N)=N)c1ccc(OCc2cccc(Cl)c2)cc1
Structure:
Search PDB for entries with ligand similarity: