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Target
Coagulation factor VII
Ligand
BDBM50148950
Substrate
n/a
Meas. Tech.
ChEBML_48454
Ki
15±n/a nM
Citation
 Klingler, O; Matter, H; Schudok, M; Donghi, M; Czech, J; Lorenz, M; Nestler, HP; Szillat, H; Schreuder, H Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition. Bioorg Med Chem Lett 14:3715-20 (2004) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50148950
Synonyms:
CHEMBL332753 | N-[1-(3-Bromo-4-morpholin-4-yl-phenyl)-ethyl]-2-[3-(4-carbamimidoyl-phenyl)-ureido]-acetamide
Type:
Small organic molecule
Emp. Form.:
C22H27BrN6O3
Mol. Mass.:
503.392
SMILES:
CC(NC(=O)CNC(=O)Nc1ccc(cc1)C(N)=N)c1ccc(N2CCOCC2)c(Br)c1
Structure:
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