Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50582407
Substrate
n/a
Meas. Tech.
ChEMBL_2154515 (CHEMBL5039175)
EC50
0.960000±n/a nM
Citation
 Jiang, S; Iliopoulos-Tsoutsouvas, C; Tong, F; Brust, CA; Keenan, CM; Raghav, JG; Hua, T; Wu, S; Ho, JH; Wu, Y; Grim, TW; Zvonok, N; Thakur, GA; Liu, ZJ; Sharkey, KA; Bohn, LM; Nikas, SP; Makriyannis, A Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists. J Med Chem 64:3870-3884 (2021) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50582407
Synonyms:
CHEMBL5071417
Type:
Small organic molecule
Emp. Form.:
C28H41NO3
Mol. Mass.:
439.63
SMILES:
[H][C@@]12C[C@H](CO)CC[C@@]1([H])C(C)(C)Oc1cc(cc(O)c21)C1(CCCCCCC#N)CCCC1 |r|
Structure:
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