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Target
Mitogen-activated protein kinase 11
Ligand
BDBM435721
Substrate
n/a
Meas. Tech.
ChEMBL_2161558 (CHEMBL5046419)
IC50
1210±n/a nM
Citation
 Abdel-Maksoud, MS; El-Gamal, MI; Lee, BS; Gamal El-Din, MM; Jeon, HR; Kwon, D; Ammar, UM; Mersal, KI; Ali, EMH; Lee, KT; Yoo, KH; Han, DK; Lee, JK; Kim, G; Choi, HS; Kwon, YJ; Lee, KH; Oh, CH Discovery of New Imidazo[2,1- J Med Chem 64:6877-6901 (2021) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41351.73
Organism:
Homo sapiens (Human)
Description:
gi_20128774
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ
  
Inhibitor
Name:
BDBM435721
Synonyms:
US10570155, Compound 25III | US11332479, Compound 25III
Type:
Small organic molecule
Emp. Form.:
C23H19FN6O3S2
Mol. Mass.:
510.564
SMILES:
Oc1cccc(c1)-c1nc2sccn2c1-c1ccnc(NCCNS(=O)(=O)c2ccc(F)cc2)n1
Structure:
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