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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50585225
Substrate
n/a
Meas. Tech.
ChEMBL_2161776 (CHEMBL5046637)
Ki
1.5±n/a nM
Citation
 Marcinkowska, M; Bucki, A; Sniecikowska, J; Zagórska, A; Fajkis-Zaj?czkowska, N; Siwek, A; Gluch-Lutwin, M; ?mudzki, P; Jastrzebska-Wiesek, M; Partyka, A; Weso?owska, A; Abram, M; Przejczowska-Pomierny, K; Cios, A; Wyska, E; Mika, K; Kota?ska, M; Mierzejewski, P; Kolaczkowski, M Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia. J Med Chem 64:12603-12629 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50585225
Synonyms:
CHEMBL5088232
Type:
Small organic molecule
Emp. Form.:
C25H26FN3O3S
Mol. Mass.:
467.556
SMILES:
C[C@H]1C[C@@H](CN1CCCc1noc2cc(F)ccc12)NS(=O)(=O)c1ccc2ccccc2c1 |r|
Structure:
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