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Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM50585252
Substrate
n/a
Meas. Tech.
ChEMBL_2161850 (CHEMBL5046711)
IC50
32±n/a nM
Citation
 Mammoliti, O; Jansen, K; El Bkassiny, S; Palisse, A; Triballeau, N; Bucher, D; Allart, B; Jaunet, A; Tricarico, G; De Wachter, M; Menet, C; Blanc, J; Letfus, V; Rup?i?, R; ?mehil, M; Poljak, T; Coornaert, B; Sonck, K; Duys, I; Waeckel, L; Lecru, L; Marsais, F; Jagerschmidt, C; Auberval, M; Pujuguet, P; Oste, L; Borgonovi, M; Wakselman, E; Christophe, T; Houvenaghel, N; Jans, M; Heckmann, B; Sanière, L; Brys, R Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases. J Med Chem 64:14557-14586 (2021) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM50585252
Synonyms:
CHEMBL5076177
Type:
Small organic molecule
Emp. Form.:
C20H18ClN3O6
Mol. Mass.:
431.826
SMILES:
COc1cc(OC)c(NC(=O)Cc2nn(CC(O)=O)c(=O)c3ccccc23)cc1Cl
Structure:
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