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Target
Carbonic anhydrase 2
Ligand
BDBM50585424
Substrate
n/a
Meas. Tech.
ChEMBL_2162454 (CHEMBL5047315)
Ki
4.9±n/a nM
Citation
 Krymov, SK; Scherbakov, AM; Salnikova, DI; Sorokin, DV; Dezhenkova, LG; Ivanov, IV; Vullo, D; De Luca, V; Capasso, C; Supuran, CT; Shchekotikhin, AE Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold. Eur J Med Chem 228:0 (2022) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50585424
Synonyms:
CHEMBL5073857
Type:
Small organic molecule
Emp. Form.:
C16H14N2O5S
Mol. Mass.:
346.358
SMILES:
COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(N)(=O)=O)cc1
Structure:
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