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Target
Geranylgeranyl pyrophosphate synthase
Ligand
BDBM50391233
Substrate
n/a
Meas. Tech.
ChEMBL_2264053
IC50
45±n/a nM
Citation
 Gendaszewska-Darmach, E; Garstka, MA; B?a?ewska, KM Targeting Small GTPases and Their Prenylation in Diabetes Mellitus. J Med Chem 64:9677-9710 (2021) [PubMed] 
Target
Name:
Geranylgeranyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:
Homooctamer; transferase
Mol. Mass.:
34867.94
Organism:
Homo sapiens (Human)
Description:
Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:
300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
  
Inhibitor
Name:
BDBM50391233
Synonyms:
CHEMBL5082037
Type:
Small organic molecule
Emp. Form.:
C15H27N3O6P2
Mol. Mass.:
407.3389
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#6]-n1cc(-[#6]-[#6](P([#8])([#8])=O)P([#8])([#8])=O)nn1
Structure:
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