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Target
Flap endonuclease 1
Ligand
BDBM50157851
Substrate
n/a
Meas. Tech.
ChEMBL_304960 (CHEMBL827838)
IC50
0.003±n/a nM
Citation
 Tumey, LN; Bom, D; Huck, B; Gleason, E; Wang, J; Silver, D; Brunden, K; Boozer, S; Rundlett, S; Sherf, B; Murphy, S; Dent, T; Leventhal, C; Bailey, A; Harrington, J; Bennani, YL The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett 15:277-81 (2004) [PubMed]  Article 
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM50157851
Synonyms:
3''-(3-Hydroxy-2,4-dioxo-3,4-dihydro-2H-thieno[3,2-d]pyrimidin-1-ylmethyl)-biphenyl-4-carboxylic acid amide | CHEMBL181962
Type:
Small organic molecule
Emp. Form.:
C20H15N3O4S
Mol. Mass.:
393.416
SMILES:
NC(=O)c1ccc(cc1)-c1cccc(Cn2c3ccsc3c(=O)n(O)c2=O)c1
Structure:
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