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Target
Cyclin-dependent kinase 2
Ligand
BDBM50588266
Substrate
n/a
Meas. Tech.
ChEMBL_2186591 (CHEMBL5098673)
IC50
84±n/a nM
Citation
Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J Med Chem 64:15189-15213 (2021) [PubMed]
More Info.:
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL