Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50161038
Substrate
n/a
Meas. Tech.
ChEMBL_306206 (CHEMBL830164)
IC50
>100±n/a nM
Citation
 Xin, Z; Zhao, H; Serby, MD; Liu, B; Schaefer, VG; Falls, DH; Kaszubska, W; Colins, CA; Sham, HL; Liu, G Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists. Bioorg Med Chem Lett 15:1201-4 (2005) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50161038
Synonyms:
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-3-methyl-phenyl)-amide | CHEMBL178329
Type:
Small organic molecule
Emp. Form.:
C22H23Cl2N3O2
Mol. Mass.:
432.343
SMILES:
CCN(CC)c1ccc(NC(=O)c2c(C)onc2-c2c(Cl)cccc2Cl)cc1C |(7.65,-1.7,;6.16,-1.26,;5.81,.25,;6.93,1.3,;6.58,2.77,;4.32,.69,;3.92,2.18,;2.46,2.58,;1.38,1.49,;-.13,1.89,;-1.2,.79,;-.81,-.68,;-2.67,1.18,;-3.09,2.67,;-2.14,3.89,;-4.61,2.74,;-5.17,1.32,;-3.95,.34,;-3.89,-1.2,;-2.51,-1.9,;-1.02,-2.29,;-2.42,-3.43,;-3.72,-4.27,;-5.1,-3.57,;-5.17,-2.04,;-6.54,-1.34,;1.78,.02,;3.27,-.37,;3.67,-1.85,)|
Structure:
Search PDB for entries with ligand similarity: