Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50161039
Substrate
n/a
Meas. Tech.
ChEMBL_306206 (CHEMBL830164)
IC50
5500±n/a nM
Citation
 Xin, Z; Zhao, H; Serby, MD; Liu, B; Schaefer, VG; Falls, DH; Kaszubska, W; Colins, CA; Sham, HL; Liu, G Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists. Bioorg Med Chem Lett 15:1201-4 (2005) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50161039
Synonyms:
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [4-(ethyl-methyl-amino)-phenyl]-amide | CHEMBL178494
Type:
Small organic molecule
Emp. Form.:
C20H19Cl2N3O2
Mol. Mass.:
404.29
SMILES:
CCN(C)c1ccc(NC(=O)c2c(C)onc2-c2c(Cl)cccc2Cl)cc1 |(8.61,2.51,;7.07,2.5,;6.32,1.16,;7.1,-.17,;4.78,1.13,;4,2.46,;2.46,2.46,;1.69,1.11,;.19,1.49,;-.89,.41,;-.48,-1.08,;-2.36,.79,;-2.77,2.28,;-1.81,3.49,;-4.29,2.36,;-4.84,.92,;-3.64,-.05,;-3.56,-1.59,;-2.18,-2.29,;-.7,-2.68,;-2.09,-3.83,;-3.4,-4.66,;-4.77,-3.97,;-4.85,-2.43,;-6.23,-1.73,;2.48,-.22,;4.02,-.19,)|
Structure:
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