Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM161571
Substrate
n/a
Meas. Tech.
ChEMBL_2196222 (CHEMBL5108738)
Ki
0.530000±n/a nM
Citation
 Zhang, Z; Bai, L; Hou, L; Deng, H; Luan, S; Liu, D; Huang, M; Zhao, L Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment. Eur J Med Chem 232:0 (2022) [PubMed] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM161571
Synonyms:
US9108983, Example 386 | US9108983, Example 449
Type:
Small organic molecule
Emp. Form.:
C41H41ClN6O4
Mol. Mass.:
717.255
SMILES:
Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Structure:
Search PDB for entries with ligand similarity: