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Target
Apoptosis regulator Bcl-2
Ligand
BDBM177786
Substrate
n/a
Meas. Tech.
ChEMBL_2196224 (CHEMBL5108740)
Ki
2.3±n/a nM
Citation
 Zhang, Z; Bai, L; Hou, L; Deng, H; Luan, S; Liu, D; Huang, M; Zhao, L Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment. Eur J Med Chem 232:0 (2022) [PubMed] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM177786
Synonyms:
US9120791, Example 1 | US9120791, Example 38 | US9603854, 38
Type:
Small organic molecule
Emp. Form.:
C43H42N4O6
Mol. Mass.:
710.8168
SMILES:
Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccccc1
Structure:
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