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Target
RNA-directed RNA polymerase
Ligand
BDBM50162510
Substrate
n/a
Meas. Tech.
ChEMBL_306584 (CHEMBL832931)
IC50
900±n/a nM
Citation
 Burton, G; Ku, TW; Carr, TJ; Kiesow, T; Sarisky, RT; Lin-Goerke, J; Baker, A; Earnshaw, DL; Hofmann, GA; Keenan, RM; Dhanak, D Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture. Bioorg Med Chem Lett 15:1553-6 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50162510
Synonyms:
(2S,4S,5R)-5-(4-Chloro-phenyl)-2-isobutyl-1-(4-trifluoromethyl-benzoyl)-pyrrolidine-2,4-dicarboxylic acid | CHEMBL413358
Type:
Small organic molecule
Emp. Form.:
C24H23ClF3NO5
Mol. Mass.:
497.891
SMILES:
CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c1ccc(cc1)C(F)(F)F)c1ccc(Cl)cc1)C(O)=O)C(O)=O
Structure:
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