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Target
Cyclin-dependent kinase 4
Ligand
BDBM50591638
Substrate
n/a
Meas. Tech.
ChEMBL_2201016 (CHEMBL5113724)
IC50
1.2±n/a nM
Citation
 Vaidya, GN; Rana, P; Venkatesh, A; Chatterjee, DR; Contractor, D; Satpute, DP; Nagpure, M; Jain, A; Kumar, D Paradigm shift of "classical" HDAC inhibitors to "hybrid" HDAC inhibitors in therapeutic interventions. Eur J Med Chem 209:0 (2021) [PubMed] 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50591638
Synonyms:
CHEMBL5190225
Type:
Small organic molecule
Emp. Form.:
C30H35F2N7O3
Mol. Mass.:
579.6408
SMILES:
CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc(CNC(=O)CCCCCCC(=O)NO)cc2)ncc1F
Structure:
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