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Target
Carbonic anhydrase 12
Ligand
BDBM50591868
Substrate
n/a
Meas. Tech.
ChEMBL_2202348 (CHEMBL5115056)
Ki
9.1±n/a nM
Citation
 Elbadawi, MM; Eldehna, WM; Nocentini, A; Somaa, WR; Al-Rashood, ST; Elkaeed, EB; El Hassab, MA; Abdel-Aziz, HA; Supuran, CT; Fares, M Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50591868
Synonyms:
CHEMBL5195261
Type:
Small organic molecule
Emp. Form.:
C20H19N3O4S
Mol. Mass.:
397.448
SMILES:
NS(=O)(=O)c1ccc(cc1)C(=O)NNCCC(=O)c1ccc2ccccc2c1
Structure:
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